TABLE 1.
Scores and mechanisms of 20 potential drugs.
| Name | Comprehensive Score | MOA (mechanism of action) |
|---|---|---|
| AS-703026 | 98.41 | MEK inhibitor |
| ISOX | 96.26 | HDAC inhibitor |
| apicidin | 96.09 | HDAC inhibitor |
| MST-312 | 96.02 | telomerase inhibitor |
| WT-171 | 94.31 | HDAC inhibitor |
| cytochalasin-b | 94.27 | microtubule inhibitor, phagocytosis inhibitor |
| vorinostat | 92.59 | HDAC inhibitor, cell cycle inhibitor |
| epoxycholesterol | 91.54 | LXR agonist |
| WYE-354 | 91.21 | mTOR inhibitor |
| SB-590885 | 91.06 | RAF inhibitor |
| cytochalasin-d | 89.01 | Actin polymerization inhibitor, actin stabilizer |
| THM-I-94 | 88.99 | HDAC inhibitor, apoptosis stimulant, cell cycle inhibitor |
| WYE-125132 | 88.82 | mTOR inhibitor, PI3K inhibitor |
| trichostatin-a | 87.17 | HDAC inhibitor, CDK expression enhancer, ID1 expression inhibitor |
| wortmannin | 86.89 | PI3K inhibitor, ATM kinase inhibitor, PLK inhibitor, etc. |
| torin-2 | 86.04 | mTOR inhibitor |
| BI-2536 | 85.47 | PLK inhibitor, apoptosis stimulant, cell cycle inhibitor, protein kinase inhibitor |
| fluticasone | 85.25 | Glucocorticoid receptor agonist |
| WAY-170523 | 85.1 | Metalloproteinase inhibitor |
| fenpiverinium | 85.05 | Acetylcholine receptor antagonist |