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. 2022 Sep 12;9:1003282. doi: 10.3389/fcvm.2022.1003282

FIGURE 3.

FIGURE 3

Pericardial-AT Exo of Adipsin overexpression mice alleviate MI-induced cardiac injury. (A) Schematic illustration of experimental procedure. MI mice were injected exosomes isolated from pericardial adipose tissue of donor mice (WT, Adipsin-KO, Adipsin-NTg, and Adipsin-Tg) on the first, third, fifth and seventh day via tail veins after MI surgery. Echocardiography and hearts collection were done 28 days after MI surgery. (B) Survival curves. Each group n = 20. *p < 0.05 vs. Sham + Vehicle group, Ip < 0.05 vs. MI + Vehicle group, § p < 0.05 vs. MI + Pericardial-AT-Exosomes from WT mice group, ¶p < 0.05 vs. MI + Pericardial-AT Exosomes from Adipsin-KO mice group, ‡p < 0.05 vs. MI + Pericardial-AT Exosomes from Adipsin-NTg mice group. (C) Representative echocardiographic images 28 days after MI surgery. (D,E) Left ventricular ejection fraction (LVEF) and fractional shortening (LVFS) of each group (n = 8–20). *p < 0.05 vs. Sham + Vehicle group, Ip < 0.05 vs. MI + Vehicle group, §p < 0.05 vs. MI + Pericardial-AT-Exosomes from WT group, ¶p < 0.05 vs. MI + Pericardial-AT Exosomes from Adipsin-KO group, ‡p < 0.05 vs. MI + Pericardial-AT Exosomes from Adipsin-NTg group. (F,G) Representative images of Masson’s trichrome staining (transverse) and quantification of fibrotic area (n = 8–20). *p < 0.05 vs. Sham + Vehicle group, Ip < 0.05 vs. MI + Vehicle group, §p < 0.05 vs. MI + Pericardial-AT-Exosomes from WT group, ¶p < 0.05 vs. MI + Pericardial-AT Exosomes from Adipsin-KO group, ‡p < 0.05 vs. MI + Pericardial-AT Exosomes from Adipsin-NTg group. Survival curves were analyzed using Gehan–Breslow–Wilcoxon test. Mean ± SEM, Data for (D,E,G) and one-way ANOVA was used for statistical analysis.