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. 2022 Sep 21;15:2003–2012. doi: 10.2147/CCID.S379609

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© 2022 Akaza et al.

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Genus classification of 16s rRNA clones in comedonal contents of inflammatory acne and on the skin surface of acne patients. (A) Individual distribution of the main bacterial genus arranged in descending order of Cutibacterium spp.; (B) boxplots of Cutibacterium and Staphylococcus spp. are shown. f, Female; m, male; T, T-zone; U, U-zone. Only bacteria with an average detection rate of 1% or higher are listed, while those with an average detection rate of less than 1% are classified as others. The Mann–Whitney U-test was employed for a statistical analysis of the skin surface of the forehead and cheek, the comedonal contents of the T-zone and U-zone, the skin surface of the forehead and the comedonal contents of T-zone, and the skin surface of cheek and the comedonal contents of the U-zone. Significant differences were observed between Cutibacterium and Staphylococcus spp. in the comedonal contents of the T-zone and on the skin surface of the forehead (P < 0.05). Significant differences were also noted between Cutibacterium and Staphylococcus spp. in the comedonal contents of the T- and U-zones (P < 0.05). No significant differences were found in any bacteria on the skin surface (forehead and cheek) or in comedonal contents (T- and U-zones) between females and males.