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Significance of compartment-level changes in structure A. and B. Differences in overall compartment size between biological replicates for those compartments that are the same (A) and different (B) type for the 2D- and 3D-cultured cells. ***, P < 0.001, Chi-squared test. C. Changes in intra-compartment contacts between 2D- and 3D-cultured cells. ***, P < 0.001, Wilcoxon rank sum test.
