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Significant changes in long-range interactions only for those TADs within B compartments A. Differences in the longer-range TAD–TAD interactions between 2D- and 3D-cultured cells. ***, P < 0.001, Wilcoxon rank sum test. B. Differences in the intra-TAD contact frequencies between 2D- and 3D-cultured cells. ***, P < 0.001, Wilcoxon rank sum test.
