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. 2022 Feb 3;20(1):70–86. doi: 10.1016/j.gpb.2022.01.005

Figure 2.

Figure 2

Identification of specialized stem-like cells (Cluster 1) with high proliferative capacity

A. Dot plot showing the relative expression levels of mesodermal progenitor cell marker genes (NG2/CSPG4, CD146/MCAM, and NES) in MSC subpopulations. The dot size indicates the percentage of cells in the cluster expressing a gene; the shading indicates the relative level of expression (low to high shown as light to dark). B. Violin plot showing the relative expression levels of the mesodermal progenitor cell marker genes (NG2/CSPG4 and NES) in MSC subpopulations. C. Comparison between single-cell transcriptomes of MSC subpopulations and cells from published datasets. Left: Heatmap displaying the correlation matrix analyzed by PCC. Right: Expression patterns of selected genes involved in the indicated biological processes between the transcriptomes of MSC subpopulations and cells from published datasets [42], including NG2+ periarteriolar cells and LEPR+ perisinusoidal cells. D. Heatmap displaying the expression patterns of selected genes involved in the indicated biological processes between each MSC subpopulation and cells from published datasets [43], including DLL1+ PXM, LTM, and ESM. E. Schematic illustrating the regulation of DEGs by potential activated TFs in Cluster 1. The potential activated TFs for Cluster 1 predicted by SCENIC are shown as diamonds, and their potential downstream targets are shown as circles. PXM, paraxial mesoderm; LTM, lateral mesoderm; ESM, early somite; PCC, pearson correlation coefficient; TF, transcription factor.