TABLE 1.
Baseline characteristics of ASCVD individuals according to ln transform systemic immune-inflammation index quartiles, weighted.
| Q1 (<5.8) | Q2 (5.8–6.2) | Q3 (6.2–6.6) | Q4 (≥6.6) | P-value | |
| Age (years) | 64.21 (62.83, 65.59) | 63.42 (61.90, 64.94) | 65.36 (64.06, 66.65) | 66.48 (65.22, 67.75) | 0.0242 |
| BMI (kg/m2) | 29.77 (29.13, 30.40) | 29.83 (29.26, 30.39) | 30.07 (29.35, 30.79) | 30.51 (29.67, 31.34) | 0.5297 |
| Waist circumference (cm) | 104.41 (103.02, 105.79) | 104.74 (103.28, 106.20) | 104.93 (103.25, 106.60) | 106.69 (104.74, 108.65) | 0.2881 |
| Family poverty income ratio | 2.65 (2.46, 2.83) | 2.50 (2.34, 2.67) | 2.58 (2.40, 2.77) | 2.43 (2.28, 2.59) | 0.3031 |
| Albumin (g/dl) | 4.19 (4.15, 4.22) | 4.19 (4.16, 4.22) | 4.14 (4.11, 4.18) | 4.08 (4.03, 4.12) | 0.0003 |
| eGFR (ml/min/1.73 m2) | 75.57 (73.21, 77.92) | 77.12 (74.62, 79.61) | 73.79 (71.43, 76.14) | 69.39 (67.43, 71.35) | < 0.0001 |
| ALT (IU/L) | 26.75 (24.96, 28.53) | 24.94 (23.02, 26.87) | 23.48 (20.96, 25.99) | 24.33 (20.15, 28.52) | 0.1821 |
| AST (IU/L) | 28.72 (27.57, 29.87) | 26.64 (25.04, 28.25) | 25.29 (24.02, 26.56) | 25.53 (23.58, 27.47) | 0.0004 |
| Total cholesterol (mg/dl) | 182.09 (178.01, 186.18) | 183.50 (179.54, 187.46) | 182.13 (177.39, 186.87) | 184.15 (179.06, 189.25) | 0.8596 |
| HbA1c (%) | 6.06 (5.97, 6.16) | 6.14 (5.99, 6.28) | 6.03 (5.92, 6.13) | 6.13 (6.01, 6.25) | 0.4715 |
| HDL cholesterol (mg/dl) | 50.79 (48.85, 52.73) | 49.50 (47.98, 51.02) | 50.69 (49.39, 51.98) | 50.78 (49.20, 52.36) | 0.6287 |
| Creatinine (mg/dl) | 1.07 (1.03, 1.11) | 1.03 (0.98, 1.07) | 1.04 (1.01, 1.07) | 1.15 (1.09, 1.22) | 0.0022 |
| Uric acid (mg/dl) | 6.02 (5.88, 6.16) | 5.75 (5.59, 5.92) | 5.93 (5.79, 6.08) | 6.13 (5.98, 6.28) | 0.0092 |
| Sex | 0.0031 | ||||
| Female | 37.87 (32.61, 43.42) | 45.33 (40.60, 50.16) | 46.22 (41.58, 50.92) | 49.80 (45.30, 54.31) | |
| Male | 62.13 (56.58, 67.39) | 54.67 (49.84, 59.40) | 53.78 (49.08, 58.42) | 50.20 (45.69, 54.70) | |
| Ethnicity | < 0.0001 | ||||
| Mexican American | 3.49 (2.46, 4.93) | 4.93 (3.51, 6.87) | 4.69 (3.02, 7.22) | 6.08 (3.98, 9.16) | |
| Non-Hispanic Black | 15.83 (12.51, 19.82) | 10.24 (8.17, 12.76) | 8.59 (6.91, 10.64) | 6.46 (4.94, 8.41) | |
| Non-Hispanic White | 72.51 (67.14, 77.30) | 75.96 (72.10, 79.44) | 79.66 (75.55, 83.23) | 79.05 (74.35, 83.08) | |
| Other | 8.17 (5.99, 11.05) | 8.87 (6.50, 12.01) | 7.05 (5.12, 9.63) | 8.42 (5.99, 11.70) | |
| Education level | 0.2045 | ||||
| Less Than High School | 27.04 (22.73, 31.83) | 25.34 (21.13, 30.07) | 26.83 (22.65, 31.47) | 27.01 (22.91, 31.54) | |
| High school or GED | 23.97 (20.49, 27.83) | 27.79 (23.54, 32.50) | 26.64 (21.81, 32.11) | 31.91 (27.61, 36.55) | |
| Above high school | 49.00 (44.01, 54.00) | 46.86 (41.75, 52.04) | 46.53 (40.27, 52.90) | 41.08 (35.84, 46.54) | |
| Marital status | 0.0002 | ||||
| Unmarried | 33.48 (28.78, 38.53) | 35.21 (30.78, 39.91) | 45.08 (40.51, 49.74) | 43.42 (38.72, 48.25) | |
| Married | 66.52 (61.47, 71.22) | 64.79 (60.09, 69.22) | 54.92 (50.26, 59.49) | 56.58 (51.75, 61.28) | |
| Malignancy | 0.4415 | ||||
| No | 81.23 (76.90, 84.90) | 80.95 (77.23, 84.19) | 78.78 (74.43, 82.57) | 77.29 (72.50, 81.46) | |
| Yes | 18.77 (15.10, 23.10) | 19.05 (15.81, 22.77) | 21.22 (17.43, 25.57) | 22.71 (18.54, 27.50) | |
| Stroke | 0.0721 | ||||
| No | 66.24 (61.38, 70.77) | 66.94 (61.55, 71.92) | 58.61 (53.97, 63.10) | 62.92 (57.77, 67.79) | |
| Yes | 33.76 (29.23, 38.62) | 33.06 (28.08, 38.45) | 41.39 (36.90, 46.03) | 37.08 (32.21, 42.23) | |
| Asthma | 0.0268 | ||||
| No | 80.31 (75.60, 84.31) | 85.08 (80.09, 88.99) | 80.00 (75.46, 83.89) | 75.98 (72.02, 79.54) | |
| Yes | 19.69 (15.69, 24.40) | 14.92 (11.01, 19.91) | 20.00 (16.11, 24.54) | 24.02 (20.46, 27.98) | |
| Diabetes | 0.3251 | ||||
| No | 69.36 (65.37, 73.08) | 67.29 (62.52, 71.73) | 69.51 (64.95, 73.71) | 64.53 (59.97, 68.84) | |
| Yes | 30.64 (26.92, 34.63) | 32.71 (28.27, 37.48) | 30.49 (26.29, 35.05) | 35.47 (31.16, 40.03) | |
| Alcohol user | 0.6014 | ||||
| Never | 46.35 (41.48, 51.29) | 50.72 (44.93, 56.49) | 47.28 (41.99, 52.64) | 52.65 (48.51, 56.75) | |
| Mild | 36.67 (31.61, 42.05) | 30.80 (26.05, 36.00) | 36.12 (31.31, 41.23) | 29.88 (25.32, 34.87) | |
| Moderate | 7.40 (4.65, 11.58) | 7.82 (5.11, 11.77) | 7.35 (5.16, 10.39) | 9.08 (7.09, 11.57) | |
| Heavy | 9.58 (7.06, 12.87) | 10.66 (7.46, 15.02) | 9.24 (6.83, 12.39) | 8.39 (5.63, 12.33) | |
| Smoke | 0.1728 | ||||
| Never | 40.28 (36.20, 44.50) | 41.96 (37.09, 46.98) | 36.54 (32.00, 41.33) | 35.73 (31.26, 40.46) | |
| Former | 38.92 (34.32, 43.74) | 36.30 (32.27, 40.54) | 43.07 (37.85, 48.44) | 38.44 (33.93, 43.16) | |
| Now | 20.80 (17.11, 25.04) | 21.74 (18.20, 25.76) | 20.39 (16.44, 25.01) | 25.83 (21.88, 30.21) | |
| Hypertension | 0.0617 | ||||
| No | 24.85 (20.29, 30.04) | 30.51 (25.62, 35.90) | 25.15 (20.70, 30.20) | 21.38 (17.66, 25.63) | |
| Yes | 75.15 (69.96, 79.71) | 69.49 (64.10, 74.38) | 74.85 (69.80, 79.30) | 78.62 (74.37, 82.34) | |
Mean for continuous variables: the p-value was calculated by the weighted linear regression. Percent for categorical variables: p-value was calculated by weighted chi-square test.