Figure 3.

Performance comparison on simulated CSVs with different match criteria

A. The sensitivity of detecting breakpoints of heterozygous CSVs. B. The sensitivity of detecting breakpoints of homozygous CSVs. C. Evaluation of reported heterozygous CSV simulation. D. Evaluation of reported homozygous CSV simulation. E. Evaluation of randomized heterozygous CSV simulation. F. Evaluation of randomized homozygous CSV simulation. The performances of selected tools for detecting simulated CSVs are evaluated according to the all-breakpoint match (A and B) and unique-interval match (C–F) criteria. In C–F, the performance is evaluated by recall (y-axis), precision (x-axis), and F1-score (dotted lines). The right top corner of the plot indicates better performance. The c5–c30 indicates coverage, e.g., c5 indicates 5× coverage.