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. 2022 Sep 12;13:997482. doi: 10.3389/fimmu.2022.997482

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Copyright © 2022 Feng, Xu, Cinquina, Wu, Zhang, Sun, Chen, Tian, Song, Pinz, Wada, Jiang, Hanes, Ma and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4-IL15/IL15sushi CAR T cells led to clinical improvements in Patient 3, diagnosed with mesenteric lymphoma, by PET-CT. (A, C, E, G) PET-CT before CD4-IL15/IL15sushi CAR T cell therapy show significant FDG uptake in mesenteric lymph nodes (circled). The larger retroperitoneal and mesenteric lymphadenopathy measure 2.4*1.7 cm, with the SUVmax of 2.1-5.2 (B, D, F, H) PET-CT 11 weeks after therapy showed reduction of mesenteric lymph node size and FDG avidity. The proto-enlarged lymph node lesions were significantly reduced or absent from before, with SUVmax of 0.9.