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. 2022 Sep 12;13:997482. doi: 10.3389/fimmu.2022.997482

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Copyright © 2022 Feng, Xu, Cinquina, Wu, Zhang, Sun, Chen, Tian, Song, Pinz, Wada, Jiang, Hanes, Ma and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Measurement of cytokines and acute phase reactants after CD4-IL15/IL15sushi CAR T cell infusion. (A) Measurement of IL-15, (B) IL-6, (C) Hs-CRP, and (D) ferritin in the blood of all three patients demonstrate low levels of IL-15 despite secretion of IL15/IL15sushi complex from CD4-IL15/IL15sushi CAR T cells and demonstrate transient, mild increases in acute phase reactants.