Table 1.
Toxicity profile of CD4-IL15/IL15sushi CAR T cells.
| Classification of adverse toxicity reactions | All levels (number of patients) | Level 1 or 2 (number of patients) | Level 3 or 4 (number of patients) | |
|---|---|---|---|---|
| Hematologic toxicity | Anemia | 2 | 1 | 1 |
| Leukopenia | 2 | 1 | 1 | |
| Neutropenia | 2 | 1 | 1 | |
| Lymphocytopenia | 3 | 2 | 1 | |
| Thrombocytopenia | 1 | 1 | 0 | |
| Infection | Transient Epstein-Barr viremia | 1 | 1 | 0 |
| Other opportunistic infections | 0 | 0 | 0 | |
| Electrolyte | Hypercalcemia | 0 | 0 | 0 |
| Hypocalcemia | 0 | 0 | 0 | |
| Hypokalemia | 0 | 0 | 0 | |
| Hyponatremia | 0 | 0 | 0 | |
| Central Nervous System | 0 | 0 | 0 | |
| Urinary System | 0 | 0 | 0 | |
| Respiratory System | 1 | 1 | 0 | |
| Digestive System | 1 | 1 | 0 | |
| Other Systems | 0 | 0 | 0 | |
| Brief Summary | 13 | 9 | 4 | |
Toxicity profile demonstrates that toxicity experienced is predominantly level 1 or 2 and predominantly limited to the hematological system.