Table 2.

Multivariate analysis of risks factors for neurocognitive decline after RT.

Neurocognitive outcome metrica	Age during RT		Time since RT
	Incidence rate ratio [95% confidence interval]	p -Value	Incidence rate ratio [95% confidence interval]	p -Value
Neurocognitive performance:
International shopping list	−0.06 [−0.20, 0.08]	NS	−0.11 [−0.23, 0.02]	NS
Network variability:
Salience	−0.001 [−0.0015, −0.0009]	<0.0001	−0.001 [−0.0014, −0.0008]	<0.0001
Frontoparietal	−0.0008	<0.002	−0.0008	<0.002
L-dorsal attention	−0.001 [−0.0015, −0.0007]	<0.0001	−0.001 [−0.0014, −0.0006]	<0.002
R-dorsal attention	−0.0015 [−0.0022, −0.0008]	<0.002	−0.0013 [−0.0020, −0.0007]	<0.002
Functional connectivity:
Modularity	−0.0055 [−0.0087, −0.0023]	<0.005	−0.0057 [−0.0087, −0.0023]	<0.002
Efficiency	−0.0017 [−0.0019, −0.0014]	<0.0001	−0.0016 [−0.0018, −0.0014]	<0.0001

^aImaging metrics represent surrogate measures of neurocognitive status and are normalized by age at the time of imaging.