Table 3.
Correlation analysis of circulating osteogenic progenitors and osteoclast precursors on hormonal and metabolic parameters of interest.
| Parameter | COP (n = 46) | CD14CD11b+(n = 46) | CD14MCSFR+(n = 45) | CD14CD120b (n = 46) | ||||
|---|---|---|---|---|---|---|---|---|
| r | (p) | r | (p) | r | (p) | r | (p) | |
| Age (years) | 0.11 | (0.47) | 0.33 | (0.02) | 0.39 | (0.009) | 0.32 | (0.03) |
| Glucose (mg/dL) | -0.08 | (0.60) | -0.32 | (0.03) | -0.35 | (0.02) | -0.32 | (0.03) |
| LDL (mg/dL) | 0.09 | (0.54) | -0.27 | (0.07) | -0.26 | (0.08) | -0.25 | (0.10) |
| HDL (mg/dL) | -0.01 | (0.97) | -0.20 | (0.19) | -0.14 | (0.37) | -0.20 | (0.19) |
| Triglycerides (mg/dL) | -0.20 | (0.19) | -0.32 | (0.03) | -0.35 | (0.02) | -0.29 | (0.05) |
| 25-OHD (ng/mL) | 0.07 | (0.63) | 0.28 | (0.06) | 0.28 | (0.06) | 0.33 | (0.03) |
| LH (mIU/mL) | -0.02 | (0.89) | 0.11 | (0.46) | -0.03 | (0.83) | 0.11 | (0.47) |
| FSH (mIU/mL) | 0.13 | (0.39) | 0.31 | (0.03) | 0.29 | (0.05) | 0.31 | (0.03) |
| Free T index | -0.28 | (0.05) | -0.24 | (0.10) | -0.22 | (0.14) | -0.22 | (0.14) |
| Free Estradiol (pmol/nmol) | -0.17 | (0.27) | -0.28 | (0.06) | -0.34 | (0.03) | -0.21 | (0.18) |
| PTH (pg/mL) | -0.24 | (0.11) | 0.01 | (0.92) | -0.03 | (0.83) | 0.11 | (0.47) |
| OCN (ng/mL) | -0.28 | (0.07) | 0.01 | (0.93) | 0.02 | (0.92) | 0.01 | (0.95) |
| CTX (ng/mL) | -0.22 | (0.17) | -0.09 | (0.60) | -0.08 | (0.63 | -0.15 | (0.37) |
| Hs-CRP (mg/L) | 0.04 | (0.78) | -0.03 | (0.84) | 0.01 | (0.94) | -0.003 | (0.98) |
| A1c at study entry (%) | -0.09 | (0.56) | -0.22 | (0.14) | -0.22 | (0.14) | -0.24 | (0.11) |
| Mean -12M A1c (%) | -0.07 | (0.71) | -0.23 | (0.13) | -0.22 | (0.14) | -0.25 | (0.098) |
| COP (%) | – | – | 0.34 | (0.02) | 0.38 | (0.01) | 0.33 | (0.03) |
Bolded p-values are statistically significant. COP, circulating osteogenic progenitors; LDL, low-density lipoprotein; HDL, high-density lipoprotein; 25-OHD, 25-hydroxyvitamin D; LH, leutinizing hormone; FSH, follicle stimulating hormone; Free T, serum free testosterone; PTH, parathyroid hormone; OCN, osteocalcin; CTX, C-telopeptide of type I collagen; Mean -12M, average of all A1c measurements between 9 and 15 months prior to study entry; hs-CRP, high-sensitivity C-reactive protein.