Figure 6.

Dose and time-effect of M101 on the alternative complement pathway (AP50/AH50). Whole uncoagulated blood from 5-6 healthy controls were pre-incubated with an increasing amount of M101 (buffer, 0.25 g/L, 0.5 g/L, 1 g/L and 5 g/L) during 30 min, 2h, 6h, 12h, 24h and 48h before being centrifugated and serum frozen (-80°C). AP50 activity was then evaluated by hemolytic activity from sera using rabbit blood cells. (A) M101 pre-incubation time effect. (B) M101 dose effect, for each concentration all time points are indicated, and results are expressed as box plots of interquartile range. P values are indicated when significant (p<0.05).