Table 3. Univariate analysis of the association between LOX family gene polymorphisms and multiple IAs ruptures.
| Gene | SNP | Genotype† | Dominant model | Recessive model | Additive model | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ruptured (n) | Unruptured (n) | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |||||
| LOX | rs1800449(C>T) | 35/25/5 | 39/28/4 | 1.05 (0.53–2.05) | 0.899 | 1.40 (0.36–5.44) | 0.631 | 1.09 (0.63–1.87) | 0.767 | |||
| rs2956540(G>C) | 27/27/11 | 31/33/7 | 1.09 (0.55–2.15) | 0.803 | 1.86 (0.68–5.14) | 0.23 | 1.22 (0.74–1.99) | 0.437 | ||||
| rs10519694(C>T) | 53/9/3 | 59/9/3 | 1.11 (0.46–2.69) | 0.812 | 1.10 (0.21–5.64) | 0.912 | 1.08 (0.56–2.08) | 0.824 | ||||
| rs2303656(G>T) | 55/10/0 | 60/11/0 | 0.99 (0.39–2.52) | 0.986 | – | – | 0.99 (0.39–2.52) | 0.986 | ||||
| rs763497(A>G) | 45/16/4 | 51/17/3 | 1.13 (0.54–2.37) | 0.740 | 1.49 (0.32–6.91) | 0.613 | 1.15 (0.64–2.06) | 0.646 | ||||
| rs3900446(A>G) | 51/14/0 | 51/17/2 | 0.70 (0.32–1.54) | 0.374 | – | – | 0.65 (0.31–1.35) | 0.248 | ||||
| LOXL1 | rs2165241(C>T) | 43/23/0 | 60/10/1 | 2.99 (1.32–6.78) | 0.009* | – | – | 2.53 (1.16–5.56) | 0.020* | |||
| rs3825942(G>A) | 46/18/1 | 52/16/3 | 1.13 (0.53–2.39) | 0.749 | 0.35 (0.04–3.49) | 0.374 | 0.99 (0.52–1.89) | 0.981 | ||||
| rs2304721(C>A) | 43/21/1 | 39/28/4 | 0.62 (0.31–1.25) | 0.183 | 0.26 (0.03–2.41) | 0.236 | 0.61 (0.33–1.13) | 0.117 | ||||
| rs12441130(T>C) | 28/31/6 | 36/26/9 | 1.36 (0.69–2.67) | 0.374 | 0.70 (2.24–2.09) | 0.523 | 1.10 (0.67–1.81) | 0.717 | ||||
| LOXL2 | rs2294128(C>T) | 47/17/1 | 53/17/1 | 1.13 (0.53–2.42) | 0.757 | 1.09 (0.07–17.85) | 0.950 | 1.11 (0.55–2.24) | 0.765 | |||
| rs7818494(A>G) | 44/19/2 | 39/28/4 | 0.58 (0.29–1.17) | 0.129 | 0.53 (0.09–3.01) | 0.475 | 0.63 (0.34–1.14) | 0.126 | ||||
| rs4323477(A>G) | 21/30/14 | 18/36/17 | 0.71 (0.34–1.50) | 0.371 | 0.87 (0.39–1.95) | 0.738 | 0.83 (0.52–1.34) | 0.446 | ||||
| rs7818416(G>A) | 21/28/16 | 21/37/13 | 0.88 (0.43–1.82) | 0.731 | 1.46 (0.64–3.32) | 0.371 | 1.07 (0.67–1.72) | 0.771 | ||||
| rs1063582(G>T) | 39/16/10 | 43/25/3 | 1.02 (0.52–2.04) | 0.947 | 4.12 (1.08–15.71) | 0.038* | 1.31 (0.78–2.18) | 0.306 | ||||
| rs2280936(C>G) | 40/20/5 | 48/20/3 | 1.30 (0.65–2.64) | 0.460 | 1.89 (0.43–8.24) | 0.397 | 1.30 (0.74–2.29) | 0.356 | ||||
| rs2294133(C>T) | 46/17/2 | 42/25/4 | 0.60 (0.29–1.22) | 0.158 | 0.53 (0.09–3.01) | 0.475 | 0.64 (0.35–1.18) | 0.153 | ||||
| rs2280935(A>C) | 33/27/5 | 28/32/11 | 0.63 (0.32–1.25) | 0.185 | 0.46 (1.15–1.39) | 0.166 | 0.65 (0.39–1.09) | 0.102 | ||||
| rs1010156(T>C) | 11/41/13 | 17/38/16 | 1.55 (0.66–3.61) | 0.314 | 0.86 (0.38–1.96) | 0.719 | 1.11 (0.66–1.87) | 0.687 | ||||
| rs142252012(G>A) | 64/1/0 | 68/3/0 | 0.35 (0.04–3.49) | 0.374 | – | – | 0.35 (0.04–3.49) | 0.374 | ||||
| LOXL3 | rs715407(T>G) | 44/20/1 | 47/22/2 | 0.94 (0.46–1.91) | 0.853 | 0.54 (0.05–6.09) | 0.617 | 0.90 (0.47–1.72) | 0.757 | |||
| rs6707302(C>T) | 46/18/1 | 51/18/2 | 1.05 (0.50–2.22) | 0.891 | 0.54 (0.05–6.09) | 0.617 | 0.99 (0.51–1.92) | 0.980 | ||||
| rs17010021(T>A) | 22/31/12 | 33/33/5 | 1.70 (0.85–3.40) | 0.135 | 2.99 (0.99–9.02) | 0.052 | 1.72 (1.03–2.89) | 0.039* | ||||
| rs17010022(C>G) | 38/22/5 | 26/33/12 | 0.41 (0.21–0.82) | 0.011* | 0.41 (0.14–1.24) | 0.113 | 0.51 (0.30–0.85) | 0.010* | ||||
| LOXL4 | rs3793692(G>A) | 18/31/16 | 17/38/16 | 0.82 (0.38–1.78) | 0.618 | 1.12 (0.51–2.48) | 0.775 | 0.97 (0.60–1.56) | 0.890 | |||
| rs1983864(G>T) | 27/31/7 | 27/33/11 | 0.86 (0.43–1.72) | 0.676 | 0.66 (0.24–1.82) | 0.419 | 0.84 (0.51–1.38) | 0.480 | ||||
| rs7077266(G>T) | 48/14/3 | 53/17/1 | 1.04 (0.48–2.25) | 0.915 | 3.39 (0.34–33.41) | 0.296 | 1.16 (0.60–2.24) | 0.649 | ||||
†, genotype presented as wild type/heterozygous/homozygous; *, P<0.05. IA, intracranial aneurysm; SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval; −, not available.