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. 2022 Sep 12;13:906468. doi: 10.3389/fphar.2022.906468

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Copyright © 2022 Suo, Hochnadel, Petriv, Franke, Schmidt, Limanska, Tugai, Jedicke, Broenstrup, Manns and Yevsa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C1 and its combination with sorafenib demonstrated inhibitory effects on HCC cell line in CCK-8 analysis and induced cellular senescence. HCC cells were treated with C1 and its combination with sorafenib and (A) 24 h and (B) 48 h after incubation cells were subjected to CCK-8 analysis at OD_450. Shown are mean ± SEM with *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. (C) SA-β-Gal assay was performed 48 h post-incubation in C1-treated group. Shown are representative bright field microscopy pictures (objective ×40). Senescent (blue) cells are depicted with white arrows.