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. 2022 Sep 12;13:906468. doi: 10.3389/fphar.2022.906468

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Copyright © 2022 Suo, Hochnadel, Petriv, Franke, Schmidt, Limanska, Tugai, Jedicke, Broenstrup, Manns and Yevsa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C1 and its combination with sorafenib induced mostly late apoptosis in HCC cells. (A) Gating strategy to analyze early, late apoptosis, and necroptosis. Cells were gated using forward- and side scatter characteristics while avoiding duplicates. The analysis of three different populations based on 7-AAD and Annexin V-PE stainings was performed. The upper left quadrant indicate necroptotic, the lower right and upper right quadrants indicate early and late apoptotic cells, respectively. The results of FACS analysis showing frequencies in percent of (B) early, (C) late apoptotic and (D) necroptotic cells are presented. DMSO and DMEM were used as carrier (negative controls) for sorafenib and C1, respectively. The grey line represents the values for the control group (DMEM).