Table 5. Cytotoxic Potency of Selected Hydrazone Derivatives^a.

Comp	human U2OS	murine MNMCA1
FG	15.9 ± 1.2b	n.d.
1	46.8 ± 12.7	38.5 ± 5.8
2	108.3 ± 35.4	28.6 ± 8.4
8	20.2 ± 1.0	23.5 ± 5.1
FIM	4.0 ± 0.33	2.3 ± 0.92
15	2.6 ± 0.87	1.9 ± 0.33
19	24.5 ± 1.2	12.1 ± 2.5
20	14.3 ± 9.3	35.7 ± 0.67
PDS	>50b	27.0 ± 16.0

^aData are IC₅₀ (μM, concentration inhibiting 50% of cell growth) of each compound in human osteosarcoma U2OS cells and murine fibrosarcoma MNMCA1 cells. Treatments were for 24 h in exponentially growing cells. Cell survival was evaluated with the MTT test after 48 h of cell recovery in drug-free medium. IC₅₀ values are means ± SEM of two independent experiments performed in triplicate.

^bSee ref (13). n.d., not determined.