Skip to main content
. 2022 Sep 16:NEJMoa2208343. doi: 10.1056/NEJMoa2208343

Figure 3. Observed Neutralizing Antibody Titers against Ancestral SARS-CoV-2 (D614G) and Omicron after 50 μg of mRNA-1273.214 or mRNA-1273 Administered as a Second Booster Dose.

Figure 3

Pseudovirus neutralizing antibody geometric mean titers are provided for all participants regardless of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection before the booster (per-protocol immunogenicity set) and for those with or without previous SARS-CoV-2 infection before the booster. Data are from participants with nonmissing data at the time point. Nine participants in the mRNA-1273 group had missing data on prebooster SARS-CoV-2 status. Antibody values that were reported as below the lower limit of quantification (18.5 for ancestral SARS-CoV-2 [D614G] and 19.9 for omicron) were replaced by 0.5 times the lower limit of qualification. Values greater than the upper limit of quantification (45,118 for ancestral SARS-CoV-2 [D614G] and 15,502.7 for omicron) were replaced by the upper limit of qualification if actual values were not available. The 95% confidence intervals (indicated by 𝙸 bars) were calculated on the basis of the t-distribution of the log-transformed values for geometric mean titer, then back-transformed to the original scale for presentation. Data for observed neutralizing antibody geometric mean titers according to previous SARS-CoV-2 infection are provided in Table S7.