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. 2022 Sep 26;41:284. doi: 10.1186/s13046-022-02493-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — AADAC is upregulated in CRC liver metastases and associated with poor prognosis. A GO analysis of the 13 most enriched lipid metabolism-related genes upregulated in LMs. B Fold change, p value and FDR of the 5 most enriched genes involved in lipid metabolic processes. C Bioinformatic analysis comparing AADAC expression levels between paired PTs and LMs from CRLM patients in 3 GEO datasets: GSE81582 (n = 19), GSE14297 (n = 18), and GSE49355 (n = 20). D Relative AADAC mRNA levels in paired PTs and LMs from CRLM patients (n = 19). E Protein expression of AADAC in paired PTs and LMs from CRLM patients (n = 10). F IHC staining of AADAC expression in paired PTs and LMs from CRLM patients (n = 157). The upper scale bar represents 500 μm. The lower scale bar represents 100 μm. G-H Relative mRNA (G) and protein (H) levels of AADAC in paired PTs and LMs from an orthotopic CRLM mouse model (n = 4). I Kaplan–Meier plots of OS and RFS after hepatectomy in CRLM patients stratified by AADAC expression in LMs and PTs. Significance was calculated by a two-tailed ratio t test (C-D, right of F, G). p value < 0.001 (***), p value < 0.01 (**), p value < 0,05 (*), ns (not significant)