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. 2022 Sep 26;159:36. doi: 10.1186/s41065-022-00249-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Explorations between clinical features and hub genes (CSF2RB, CD53 and LAPTM5) in human tubulointerstitial samples. A The mRNA expression of CSF2RB was negatively correlated with GFR (MDRD). B The mRNA expression of CSF2RB was negatively correlated with GFR (CG). C The mRNA expression of CD53 was negatively correlated with GFR (MDRD). D The mRNA expression of LAPTM5 was negatively correlated with GFR (MDRD). E The mRNA expression of CD53 was positively correlated with proteinuria. F The mRNA expression of LAPTM5 was positively correlated with proteinuria. G The mRNA expression of LAPTM5 in nephrotic proteinuria group was higher than that of subnephrotic proteinuria group. H The mRNA expression of CSR2RB was negatively correlated with age. I The mRNA expression of CD53 was negatively correlated with age. J The mRNA expression of LAPTM5 was negatively correlated with age. GFR: glomerular filtration rate; MDRD: modification of diet in renal disease; CG: Cockcroft Gault; *: p < 0.05; P < 0.05 was considered significant