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. 2022 Jun 21;5(3):625–636. doi: 10.20517/cdr.2022.34

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© The Author(s) 2022.

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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AdipoRon-mediated mechanisms and potential interconnection points to overcome gemcitabine resistance in PDAC. Schematic representation of the main metabolic and signaling pathways regulated by AdipoRon in PDAC cells. Red arrows indicate direct and indirect AdipoRon-related ways to hinder chemotherapy resistance.