Table 1.

Key molecules transferred by MVs modulating sorafenib resistance

Key molecules	MVs sources	Function	Ref.
miR-25	HCC cells	Increase sorafenib resistance	[15]
miR-494-3p	GOLPH3 overexpressed HCC cells	Promote the angiogenesis ability of HUVECs and induce sorafenib resistance in HCC cells	[87]
lnc-ROR	HCC cells	Reduce chemotherapy-induced cell death	[88]
lnc-VLDLR	HCC cells	Reduce chemotherapy-induced cell death	[89]
miR-199a	Adipose tissue derived MSCs	Increase chemosensitivity in HCC	[90]
miR-122	Adipose tissue derived MSCs	Increase chemosensitivity in HCC	[91]
miR-214	Human cerebral endothelial cells	Sensitize HCC cells to sorafenib treatment	[92]
siGRP78	Modified bone-marrow-derived mesenchymal stem cells	Suppress sorafenib resistance	[93]

MVs: Microvesicles; HCC: hepatocellular carcinoma.