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. Author manuscript; available in PMC: 2022 Sep 26.
Published in final edited form as: Bioorg Med Chem Lett. 2020 Sep 12;30(24):127543. doi: 10.1016/j.bmcl.2020.127543

Scheme 3.

Scheme 3.

Synthesis of intermediates 25a and 25b. Reagents and conditions: (a) NaOMe, MeOH, 0 °C to rt, 16 h, 55 and 77%. (b) For 25a: Et Zn, CH o2 2I2, toluene, −20 °C, 3 h, 76%. For 25b: Et2Zn, CH2I2, toluene, −78 °C to rt, 16 h (dr 6:1), 98%.