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. Author manuscript; available in PMC: 2022 Sep 26.
Published in final edited form as: Bioorg Med Chem Lett. 2020 Sep 12;30(24):127543. doi: 10.1016/j.bmcl.2020.127543

Table 2.

CpIMPDH and HsIMPDH inhibitory activities of 18, 31a, 31b, 38, 42a, 42b and 44.

graphic file with name nihms-1636360-t0003.jpg
Compound R1 X CpIMPDH
Ki,app (μM)		 HsIMPDH
Ki,app (μM)
18 3-CF3, 4-Cl graphic file with name nihms-1636360-t0004.jpg 0.060 (±0.01)r ND*
31a 3-CF3, 4-Cl graphic file with name nihms-1636360-t0005.jpg 0.57 1.40
31b 3-CF3, 4-Cl graphic file with name nihms-1636360-t0006.jpg 0.066 (±0.023)σ 0.46 (±0.28)σ
38 4-Cl graphic file with name nihms-1636360-t0007.jpg 0.405 (±0.176)r 0.87
42a 4-Cl graphic file with name nihms-1636360-t0008.jpg 0.48 0.55
42b 4-Cl graphic file with name nihms-1636360-t0009.jpg 0.45 (±0.13)r 0.29
44 4-Cl graphic file with name nihms-1636360-t0010.jpg 2.8 0.8
*

ND: Not Determined

σ:

Standard deviation

r:

Range