Table 18.
Frequency and respective percentage of mutations detected in each invariant residue window of S proteins.
| S proteins invariant residues |
Number of mutations |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Invariant residues | Total # of residues | Domain | Tunisia | Texas | Spain | Serbia | Poland | Peru | Pennsylvania | Pakistan | Minnesota | Michigan | Massachusetts |
| 34–38 | 5 | S1 | 0 | 5 | 0 | 0 | 0 | 0 | 4 | 0 | 1 | 1 | 5 |
| 102–104 | 3 | S1 | 0 | 3 | 0 | 0 | 0 | 3 | 3 | 1 | 3 | 3 | 3 |
| 165–167 | 3 | S1 | 0 | 3 | 0 | 0 | 0 | 0 | 3 | 0 | 3 | 3 | 3 |
| 189–191 | 3 | S1 | 0 | 3 | 0 | 0 | 1 | 1 | 3 | 0 | 3 | 1 | 3 |
| 281–284 | 4 | S1 | 0 | 4 | 0 | 0 | 0 | 4 | 4 | 0 | 4 | 4 | 4 |
| 310–320 | 11 | S1 | 1 | 11 | 0 | 0 | 0 | 0 | 11 | 0 | 11 | 11 | 11 |
| 374–383 | 10 | S1 | 0 | 7 | 0 | 0 | 0 | 10 | 4 | 0 | 3 | 3 | 10 |
| 418–429 | 12 | S1 | 0 | 12 | 0 | 0 | 0 | 3 | 1 | 0 | 3 | 1 | 12 |
| 509–518 | 10 | S1 | 0 | 10 | 6 | 0 | 0 | 0 | 10 | 0 | 10 | 9 | 10 |
| 520–528 | 9 | S1 | 1 | 9 | 4 | 0 | 0 | 0 | 2 | 0 | 9 | 2 | 9 |
| 538–546 | 9 | S1 | 0 | 9 | 0 | 1 | 0 | 0 | 1 | 0 | 2 | 0 | 9 |
| 591–603 | 13 | S1 | 0 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4 |
| 608–618 | 11 | S1 | 1 | 11 | 1 | 1 | 1 | 1 | 6 | 1 | 6 | 4 | 4 |
| 659–674 | 16 | S1 | 0 | 16 | 0 | 0 | 0 | 0 | 14 | 1 | 15 | 7 | 4 |
| 751–767 | 17 | S2 | 0 | 8 | 1 | 0 | 0 | 0 | 14 | 0 | 11 | 7 | 14 |
| 797–809 | 13 | S2 | 0 | 6 | 2 | 0 | 0 | 0 | 5 | 0 | 11 | 1 | 13 |
| 814–833 | 18 | S2 and S2’ | 0 | 11 | 0 | 0 | 0 | 0 | 9 | 14 | 18 | 8 | 19 |
| 846–867 | 22 | S2’ | 0 | 12 | 0 | 0 | 0 | 2 | 8 | 3 | 6 | 5 | 5 |
| 885–921 | 37 | S2’ | 2 | 16 | 0 | 0 | 0 | 3 | 5 | 1 | 36 | 31 | 8 |
| 944–1044 | 101 | S2’ | 2 | 88 | 1 | 1 | 1 | 3 | 14 | 1 | 72 | 64 | 28 |
| 1074–1083 | 10 | S2’ | 0 | 4 | 0 | 1 | 0 | 2 | 4 | 1 | 5 | 3 | 2 |
| 1090–1096 | 7 | S2’ | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 5 | 7 | 2 |
| 1115–1122 | 8 | S2’ | 1 | 4 | 1 | 0 | 1 | 1 | 5 | 1 | 5 | 3 | 5 |
| 1134–1163 | 30 | S2’ | 0 | 24 | 1 | 0 | 1 | 0 | 8 | 3 | 19 | 8 | 9 |
| 1165–1190 | 26 | S2’ | 0 | 25 | 0 | 0 | 0 | 3 | 12 | 1 | 24 | 7 | 12 |
| 1192–1207 | 16 | S2’ | 0 | 10 | 1 | 0 | 1 | 0 | 7 | 1 | 16 | 5 | 5 |
| 1209–1229 | 21 | S2’ (1214–1229-TMD) | 0 | 19 | 0 | 1 | 1 | 1 | 8 | 2 | 21 | 5 | 14 |
| 1234–1246 | 13 | S2’ (1234-TMD) | 2 | 13 | 0 | 0 | 0 | 0 | 9 | 0 | 8 | 4 | 7 |
| 1262–1273 | 12 | S2’ | 0 | 4 | 0 | 0 | 1 | 0 | 3 | 1 | 4 | 4 | 5 |
| S proteins invariant residues |
Number of mutations |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Invariant residues | Total # of residues | Domain | India | Hong Kong | Greece | Ghana | France | Florida | Egypt | Chile | California | Bangladesh | Bahrain | Austria | Australia |
| 34–38 | 5 | S1 | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5 | 2 | 0 | 0 | 2 |
| 102–104 | 3 | S1 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 3 | 1 | 1 | 0 | 3 |
| 165–167 | 3 | S1 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 3 | 0 | 0 | 0 | 3 |
| 189–191 | 3 | S1 | 1 | 0 | 0 | 1 | 0 | 3 | 0 | 0 | 3 | 1 | 0 | 0 | 2 |
| 281–284 | 4 | S1 | 0 | 0 | 0 | 4 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 | 4 |
| 310–320 | 11 | S1 | 0 | 1 | 0 | 11 | 0 | 11 | 1 | 0 | 11 | 0 | 0 | 11 | 11 |
| 374–383 | 10 | S1 | 4 | 0 | 0 | 0 | 2 | 2 | 3 | 10 | 9 | 10 | 0 | 0 | 0 |
| 418–429 | 12 | S1 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 3 | 0 | 0 | 0 | 0 |
| 509–518 | 10 | S1 | 0 | 10 | 0 | 1 | 0 | 10 | 0 | 0 | 10 | 1 | 1 | 0 | 10 |
| 520–528 | 9 | S1 | 0 | 9 | 0 | 0 | 0 | 3 | 2 | 0 | 8 | 1 | 0 | 0 | 9 |
| 538–546 | 9 | S1 | 0 | 0 | 0 | 0 | 0 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 591–603 | 13 | S1 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 5 | 1 | 0 | 0 | 1 |
| 608–618 | 11 | S1 | 1 | 1 | 1 | 2 | 2 | 11 | 2 | 1 | 6 | 1 | 1 | 1 | 2 |
| 659–674 | 16 | S1 | 0 | 0 | 0 | 1 | 0 | 16 | 0 | 0 | 11 | 1 | 0 | 0 | 6 |
| 751–767 | 17 | S2 | 0 | 0 | 0 | 0 | 0 | 7 | 1 | 1 | 14 | 0 | 0 | 1 | 9 |
| 797–809 | 13 | S2 | 5 | 0 | 0 | 2 | 0 | 5 | 3 | 0 | 10 | 13 | 0 | 0 | 1 |
| 814–833 | 18 | S2 and S2’ | 6 | 1 | 0 | 1 | 0 | 7 | 3 | 0 | 10 | 4 | 1 | 0 | 2 |
| 846–867 | 22 | S2’ | 0 | 0 | 0 | 0 | 0 | 15 | 1 | 0 | 10 | 0 | 0 | 0 | 2 |
| 885–921 | 37 | S2’ | 1 | 0 | 1 | 1 | 0 | 6 | 1 | 0 | 32 | 0 | 1 | 1 | 3 |
| 944–1044 | 101 | S2’ | 1 | 2 | 0 | 2 | 1 | 48 | 5 | 0 | 93 | 4 | 3 | 3 | 12 |
| 1074–1083 | 10 | S2’ | 2 | 0 | 0 | 1 | 0 | 10 | 8 | 1 | 4 | 1 | 1 | 0 | 3 |
| 1090–1096 | 7 | S2’ | 1 | 1 | 0 | 1 | 0 | 4 | 7 | 0 | 5 | 2 | 1 | 0 | 1 |
| 1115–1122 | 8 | S2’ | 3 | 1 | 1 | 2 | 0 | 8 | 1 | 0 | 6 | 2 | 1 | 2 | 2 |
| 1134–1163 | 30 | S2’ | 3 | 0 | 0 | 3 | 1 | 14 | 3 | 0 | 25 | 0 | 3 | 0 | 6 |
| 1165–1190 | 26 | S2’ | 5 | 2 | 0 | 0 | 0 | 16 | 2 | 0 | 24 | 3 | 0 | 0 | 2 |
| 1192–1207 | 16 | S2’ | 1 | 0 | 0 | 0 | 0 | 14 | 0 | 0 | 16 | 0 | 0 | 2 | 0 |
| 1209–1229 | 21 | S2’ (1214–1229-TMD) | 0 | 0 | 0 | 3 | 0 | 14 | 1 | 1 | 21 | 0 | 0 | 0 | 4 |
| 1234–1246 | 13 | S2’ (1234-TMD) | 1 | 0 | 0 | 1 | 0 | 7 | 4 | 1 | 13 | 2 | 1 | 0 | 7 |
| 1262–1273 | 12 | S2’ | 2 | 0 | 1 | 0 | 1 | 4 | 7 | 0 | 9 | 4 | 1 | 1 | 4 |