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. Author manuscript; available in PMC: 2023 Mar 15.
Published in final edited form as: Biol Psychiatry. 2021 Jul 11;91(6):561–571. doi: 10.1016/j.biopsych.2021.06.024

Figure 5. Visualization of the associations between regional circuit clinical scores and phenotypes.

Figure 5.

The observed relationships between regional circuit clinical scores (bottom half of each circle; below the dotted line) and symptom and/or behavioral phenotypes (top half of each circle; above the dotted line), guided by our theoretical synthesis (A=default mode circuit, B=salience circuit, C=attention circuit, D=negative affect circuit elicited by sad, E=negative affect circuit elicited by threat, F=positive affect circuit, G=cognitive control circuit). Relationships in primary sample A (i.e., uncorrected p<0.05) are illustrated by thicker, darker lines, with the color representing the specific circuit involved and the thickness representing the magnitude of effect size (standardized regression coefficient values) and consistency of effects across samples.

a Relationships observed at an uncorrected p<0.05.

Abbreviations: AG = Angular Gyrus; aI = anterior Insula; aIPL = anterior Inferior Parietal Lobule; amPFC = anterior medial Prefrontal Cortex; Amy = Amygdala; dACC = dorsal Anterior Cingulate Cortex; DLPFC = Dorsal Lateral Prefrontal cortex; L = Left; LPFC = Lateral Prefrontal Cortex; vmPFC = ventromedial Prefrontal Cortex; msPFC = medial superior Prefrontal Cortex; pgACC = pregenual Anterior Cingulate Cortex; PCC = Posterior Cingulate Cortex; PCu = Precuneus; R = Right; RT = Reaction Time; vStriatum = ventral Striatum.