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. 2022 Sep 26;2022(9):CD011642. doi: 10.1002/14651858.CD011642.pub2

Comparison 3. Fractional carbon dioxide (CO2) versus no treatment.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
3.1 Severity of scar: Vancouver Burn Scar (VBS) scale (up to 6 months) 2   Mean Difference (IV, Random, 95% CI) Subtotals only
3.1.1 Hypertrophic scar 2 104 Mean Difference (IV, Random, 95% CI) ‐1.30 [‐4.32, 1.71]
3.1.2 Keloid scar 1 36 Mean Difference (IV, Random, 95% CI) ‐1.90 [‐3.02, ‐0.78]
3.2 Severity of scar: Patient and Observer Scar Assessment Scale (POSAS) (at least one month) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
3.3 Scar size, colour, height, length, width, pliability, skin surface texture, pruritus and pain (12 to 18 weeks) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
3.3.1 Height 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
3.3.2 Erythema 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
3.3.3 Pigmentation 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
3.3.4 Pain not related to treatment 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
3.3.5 Pruritus 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected