IRCT2016052318210N7.

Study name	Treatment of burn scars using ablative CO2 fractional laser and topical rapamycin (sirolimus)
Methods	Randomised open‐label controlled trial
Participants	Patients with burn hypertrophic scar who will come to RasoulAkram hospital, excluding: pregnancy or breastfeeding women, and psychological disorders that could not understand or fill consent inform.
Interventions	Intervention 1: CO2 fractional laser: device will set with skin types of participants, anatomic place and scars colour and depth. Laser will be applied in 3 sections monthly. Intervention 2: Rapamycin cream: participants will be treated with Rapamycin 1% cream for 12 weeks. Intervention 3: combination therapy of CO2 fractional laser (on burn scars that will be applied in 3 sections monthly) added with Rapamayci 1% Cream.
Outcomes	Primary outcome: contracture and texture. Secondary outcomes: satisfaction, skin colour, atrophy.
Starting date	Not reported
Contact information	Elham Behrangi:  Hazrat‐e Rasool General Hospital  Niyayesh St. Satarkhan St. Tehran Iran Tel:+98 (21) 66517341‐9: Elham.Behrangi@gmail.com
Notes