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. 2022 Sep 13;65(18):12445–12459. doi: 10.1021/acs.jmedchem.2c01149

Figure 2.

Figure 2

(A) Co-crystal X-ray structure showing the (S)-enantiomer of HA compound 3 at 2.1 Å resolution (PDB: 6FYZ), and (B) TFMO compound 4 docked into the HDAC4 active site, each illustrating a suitable site of attachment for a tether to the E3 ligase ligand.