Table 2.

Proteomics Combined with Transcriptomics Analysis

Quadrant	Gene Symbol
1, 9	IGF1, CD44, MMP8, LDHB, PDGFB, GALT, ADA2, FCGBP
2, 8	DMBT1, TDRD9, MMRN1, PCSK9, GGH, C1QC, AHSP, C1RL, VASP, HBD, EFNA1, MSRA, PRL, TIMP3, APMAP, ASPG, PRDX5, C1QB, ZYX, C4BPA, SQOR, RAB7A, CAMP, ITIH4, QPCT, IGLL5, PLTP, LOXL1, CLIC1, CFLAR, CD27, DSC1, MMRN2, PTGDS, FSBP, RASA3
3, 7	SDC1, TIMP1, MMP2, LDHA, OIT3, GRN, RETN, S100P, C1QA, SYCP2, CD59, PRTN3, GSTO1, SLPI, QSOX1, HSPB6, MT1G, NQO2, ANXA1, MMP25, RHOG, PTX3, GHRL, MZB1, BUB1B, PRDX3, CHAD, NPTXR, KLKB1, ABI2, TDRD1
4, 6	EXTL2, HYAL1, ITIH2, ZBED1, DPM3, PROC, PRDX2, EHD1, HMGB1, MMP14, MGAT1, KHNYN, OAF, FBLN1, PDCD6, LTBP2, GANAB, CSF1, ACTB, ECI1, CD14, LMAN2, BTD, PDIA6, SAR1B, UFM1, BMP1, ERN1, INHBE, FIS1, CDC42, FAM3C, ARPC4, MIF, RAC1, GSTM2, MGLL, ARF1, BRK1, ALDOA, CRIP1, DCXR, BIN2, NPC2, HINT1, ATOX1, MOB1B, HCLS1, FAHD1, GPX1, ACTN4, FKBP3, HERC1, HNMT
5	HSPB1, DSC3, THRB, DHX29, APOM, MMP15, TGFB1, APOC1, PPIA, PEF1, HEXB, ATG10, C1R, KNG1, HBG1, C4BPB, MUC5B, PDS5A, GPX3, HBB, RHOA, VASN, FABP5, ITM2B, PRG4, LEP, APOE, CD99, UBE2N, SUMO4, PEBP4, LTBP1, RAP1B, SRP72, CNN2, FGL2, RSU1, RAB6A, AMY2B, GOLM1, CLN3, APOL1, PRDX6, GSTK1, SRC, ENPP2, COTL1, BLVRB, GSTM3, HBG2, LY6D, TAB2, SMC3, PXDN, CALD1, TSTD1, BID, PEPD, AIF1, PLEK, MGP, GSTP1, DNM1L, BCR, PRDX1, FLNA, TLN1, ILK, RAC2, YLPM1, CPNE8, UBA1, TPP1

Notes: Nine-quadrant analysis showed that a total of 203 intersection targets were screened by the combined analysis of the two histologies, of which 8 targets, including IGF1, CD44, and MMP8, etc were located in quadrants 1 or 9. 36 targets, including DMBT1, TDRD9, PCSK9, etc were located in quadrants 2 or 8. The 31 targets of GSTO1, C1QA, RETN, GRN, etc. were located in the 3 or 7 quadrants. 54 targets such as EXTL2, HYAL1, ITIH2, etc were located in quadrants 4 or 6. 73 targets such as HSPB1, DSC3, THRB, etc were located in quadrant 5.