Table 3.
Risk Analysis for ZBTB20 Polymorphisms and Esophageal Cancer in Different Genetic Models by Logistic Regression Analysis
| SNP | Model | Genotype | Controls | Esophageal Cancer | Esophageal Squamous Cell Carcinoma | ||||
|---|---|---|---|---|---|---|---|---|---|
| Cases | OR (95% CI) | p-value | Cases | OR (95% CI) | p-value | ||||
| rs10934270 | Allele | C | 936 | 978 | 1 | 719 | 1 | ||
| T | 108 | 72 | 0.64 (0.47–0.87) | 0.004* | 55 | 0.66 (0.47–0.93) | 0.017 | ||
| Genotype | CC | 422 | 455 | 1 | 334 | 1 | |||
| CT | 92 | 68 | 0.68 (0.49–0.96) | 0.029 | 51 | 0.70 (0.48–1.02) | 0.061 | ||
| TT | 8 | 2 | 0.23 (0.05–1.10) | 0.065 | 2 | 0.32 (0.07–1.50) | 0.147 | ||
| Dominant | CC | 422 | 455 | 1 | 334 | 1 | |||
| CT-TT | 100 | 70 | 0.65 (0.46–0.91) | 0.011* | 53 | 0.67 (0.47–0.96) | 0.031 | ||
| Recessive | CC-CT | 514 | 523 | 1 | 385 | 1 | |||
| TT | 8 | 2 | 0.25 (0.05–1.16) | 0.077 | 2 | 0.33 (0.07–1.58) | 0.167 | ||
| Log-additive | 0.64 (0.47–0.88) | 0.005* | 0.67 (0.48–0.94) | 0.020 | |||||
| rs9288999 | Allele | A | 594 | 613 | 1 | 462 | 1 | ||
| G | 448 | 437 | 0.95 (0.79–1.12) | 0.524 | 312 | 0.90 (0.74–1.08) | 0.252 | ||
| Genotype | AA | 170 | 180 | 1 | 137 | 1 | |||
| AG | 254 | 253 | 0.94 (0.72–1.24) | 0.665 | 188 | 0.92 (0.69–1.23) | 0.572 | ||
| GG | 97 | 92 | 0.90 (0.63–1.28) | 0.551 | 62 | 0.79 (0.54–1.17) | 0.249 | ||
| Dominant | AA | 170 | 180 | 1 | 137 | 1 | |||
| AG-GG | 351 | 345 | 0.93 (0.72–1.20) | 0.578 | 250 | 0.88 (0.67–1.17) | 0.387 | ||
| Recessive | AA-AG | 424 | 433 | 1 | 325 | 1 | |||
| GG | 97 | 92 | 0.93 (0.68–1.28) | 0.654 | 62 | 0.84 (0.59–1.19) | 0.314 | ||
| Log-additive | 0.95 (0.80–1.13) | 0.535 | 0.90 (0.74–1.08) | 0.256 | |||||
| rs9841504 | Allele | C | 899 | 896 | 1 | 649 | 1 | ||
| G | 145 | 154 | 1.07 (0.83–1.36) | 0.611 | 125 | 1.19 (0.92–1.55) | 0.180 | ||
| Genotype | CC | 384 | 386 | 1 | 275 | 1 | |||
| CG | 131 | 124 | 0.94 (0.71–1.25) | 0.664 | 99 | 1.06 (0.78–1.43) | 0.731 | ||
| GG | 7 | 15 | 2.12 (0.85–5.26) | 0.106 | 13 | 2.59 (1.02–6.59) | 0.045 | ||
| Dominant | CC | 384 | 386 | 1 | 275 | 1 | |||
| CG-GG | 138 | 139 | 1.00 (0.76–1.32) | 0.992 | 112 | 1.13 (0.84–1.52) | 0.408 | ||
| Recessive | CC-CG | 515 | 510 | 1 | 374 | 1 | |||
| GG | 7 | 15 | 2.15 (0.87–5.33) | 0.098 | 13 | 2.56 (1.01–6.47) | 0.047 | ||
| Log-additive | 1.06 (0.83–1.36) | 0.630 | 1.19 (0.92–1.55) | 0.183 | |||||
| rs73230612 | Allele | T | 610 | 626 | 1 | 450 | 1 | ||
| C | 434 | 424 | 0.95 (0.80–1.13) | 0.580 | 324 | 1.01 (0.84–1.22) | 0.902 | ||
| Genotype | TT | 181 | 184 | 1 | 127 | 1 | |||
| TC | 248 | 258 | 1.03 (0.78–1.34) | 0.853 | 196 | 1.13 (0.84–1.52) | 0.416 | ||
| CC | 93 | 83 | 0.88 (0.61–1.26) | 0.475 | 64 | 0.98 (0.66–1.45) | 0.920 | ||
| Dominant | TT | 181 | 184 | 1 | 127 | 1 | |||
| TC-CC | 341 | 341 | 0.99 (0.76–1.27) | 0.907 | 260 | 1.09 (0.82–1.44) | 0.549 | ||
| Recessive | TT-TC | 429 | 422 | 1 | 323 | 1 | |||
| CC | 93 | 83 | 0.86 (0.62–1.20) | 0.378 | 64 | 0.91 (0.64–1.29) | 0.606 | ||
| Log-additive | 0.95 (0.80–1.13) | 0.580 | 1.01 (0.84–1.22) | 0.899 | |||||
Notes: p values were calculated by logistic regression analysis with adjustments for age and gender. Bold p < 0.05 respects the data is statistically significant. *p indicate that after Bonferroni correction (p < 0.05/4) means the data is statistically significant.
Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval.