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. 2022 Sep 12;10:979269. doi: 10.3389/fcell.2022.979269

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Copyright © 2022 Andrade-Alviárez, Bonive-Boscan, Cáceres, Quiñones, Gualdrón-López, Ginger and Michels.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Major pathways of glycosomal carbon metabolism in TriTryps species. Indicated are enzymes of glycolysis, its auxiliary branches, gluconeogenesis, glycerol metabolism and the pentose-phosphate pathway. Note that not all enzymes indicated are present in each of the TriTryps species or expressed in each of their life-cycle stages. Enzymes: 1. Hexokinase; 2. Glucose-6-phosphate isomerase; 3. Phosphofructokinase; 4. Aldolase; 5. Triose-phosphate isomerase; 6. Glyceraldehyde-3-phosphate dehydrogenase; 7. Phosphoglycerate kinase; 8. Phosphoglycerate mutase; 9. Enolase; 10. Pyruvate kinase; 11. Phosphoenolpyruvate carboxykinase; 12. Pyruvate phosphate dikinase; 13. Alanine dehydrogenase; 14. Malate dehydrogenase; 15. Fumarate hydratase; 16. NADH-dependent fumarate reductase; 17. Glycerol-3-phosphate dehydrogenase; 18. Glycerol kinase; 19. Fructose-1,6-bisphosphatase; 20. Glucokinase; 21. d-Hexose-6-Phosphate-1-epimerase; 22. Glucose-6-phosphate dehydrogenase; 23. 6-Phosphogluconolactonase; 24; 6-Phosphogluconate dehydrogenase; 25. Ribulose-5-phosphate epimerase; 26. Ribulose-5-phosphate isomerase; 27. Ribokinase; 28. Transketolase; 29. Transaldolase; 30. Sedoheptulose-1,7-phosphate transaldolase; 31. Sedoheptulose-1,7-bisphosphatase; 32. Adenylate kinase; 33. Arginine kinase; 34. Isocitrate dehydrogenase. The presence of a PTS1 or 2, the carbon sources used, and the excreted end products are indicated.