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. 2022 Sep 12;10:979269. doi: 10.3389/fcell.2022.979269

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Copyright © 2022 Andrade-Alviárez, Bonive-Boscan, Cáceres, Quiñones, Gualdrón-López, Ginger and Michels.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationships between isocitrate dehydrogenase (IDH) sequences. The evolutionary history of IDH sequences was inferred by methods described in the legend of Figure 3. The analysis involved 40 amino-acid sequences, with a total of 319 positions in the final dataset. The stars indicate sequences with a PTS1. The following IDH sequences were retrieved from the NCBI: H. sapiens, S. cerevisiae, E. coli, T. borreli, D. papillatum, D. japonicum, E. longa, and E. gracilis, whereas for Naegleria spp. the sequences were retrieved from AmoebaDB. The other euglenozoan sequences were taken from TriTrypDB.