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. 2022 Sep 12;10:979269. doi: 10.3389/fcell.2022.979269

FIGURE 8.

FIGURE 8

Glycosomal homeostasis of cofactors. Glycosomes harbour a pool of adenine nucleotides and nicotinamide-adenine nucleotides, separate from the cytosolic pool, that is involved in various branches of glycosomal catabolism and anabolism. The presence or absence of PTS motifs suggests that enzymes of the metabolic processes listed in the figure were sequestered at different stages in the evolution of glycosomes: already present in peroxisomes of ancestral organisms (blue); sequestered within glycosomes during or shortly after the origin of these organelles from peroxisomes (red); sequestered only in kinetoplastids at an early stage (mauve); sequestered late in glycosomes of some taxa (green). However, it should be noted that specific enzymes of some processes mentioned in the figure were not compartmentalised or even lost from all or certain taxa, as described in the text.