Comparison 14. IDS: LVRD (> 1 cm) versus SVRD (< 1 cm).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
14.1 Overall survival	1		Hazard Ratio (IV, Random, 95% CI)	1.02 [0.68, 1.55]
14.1.1 ≤ 4 cycles of NACT	1		Hazard Ratio (IV, Random, 95% CI)	1.13 [0.58, 2.19]
14.1.2 > 4 cycles of NACT	1		Hazard Ratio (IV, Random, 95% CI)	0.96 [0.57, 1.63]
14.2 Overall survival sensitivity analysis including 0 cm	6		Hazard Ratio (IV, Random, 95% CI)	1.60 [1.21, 2.11]
14.2.1 3 cycles of NACT	2		Hazard Ratio (IV, Random, 95% CI)	1.80 [0.94, 3.43]
14.2.2 Median 4 cycles of NACT (disease‐specific survival)	1		Hazard Ratio (IV, Random, 95% CI)	1.70 [1.06, 2.75]
14.2.3 Mean/median ~ 6 cycles of NACT	2		Hazard Ratio (IV, Random, 95% CI)	2.19 [1.07, 4.50]
14.2.4 ≤ 4 cycles of NACT	1		Hazard Ratio (IV, Random, 95% CI)	1.13 [0.58, 2.19]
14.2.5 > 4 cycles of NACT	1		Hazard Ratio (IV, Random, 95% CI)	0.96 [0.57, 1.63]
14.3 Overall survival sensitivity analysis excluding Phillips 2018	5		Hazard Ratio (IV, Random, 95% CI)	1.84 [1.34, 2.52]
14.3.1 3 cycles of NACT	2		Hazard Ratio (IV, Random, 95% CI)	1.80 [0.94, 3.43]
14.3.2 Median 4 cycles of NACT (disease‐specific survival)	1		Hazard Ratio (IV, Random, 95% CI)	1.70 [1.06, 2.75]
14.3.3 Mean/median ~ 6 cycles of NACT	2		Hazard Ratio (IV, Random, 95% CI)	2.19 [1.07, 4.50]
14.4 Progression‐free survival	4		Hazard Ratio (IV, Random, 95% CI)	1.76 [1.23, 2.52]
14.4.1 3 cycles of NACT	2		Hazard Ratio (IV, Random, 95% CI)	1.68 [0.90, 3.14]
14.4.2 Mean ~ 6 cycles of NACT	1		Hazard Ratio (IV, Random, 95% CI)	2.32 [1.08, 4.97]
14.4.3 All cycles	1		Hazard Ratio (IV, Random, 95% CI)	1.82 [1.12, 2.97]