Comparison 15. IDS: RD > 0 cm versus NMRD.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
15.1 Overall survival	4		Hazard Ratio (IV, Random, 95% CI)	2.11 [1.35, 3.29]
15.1.1 Median 6 cycles of NACT	2		Hazard Ratio (IV, Random, 95% CI)	3.03 [1.68, 5.48]
15.1.2 Median 4 cycles of NACT	1		Hazard Ratio (IV, Random, 95% CI)	1.29 [0.98, 1.70]
15.1.3 All cycles	1		Hazard Ratio (IV, Random, 95% CI)	2.04 [1.53, 2.72]
15.2 Progression‐free survival	1		Hazard Ratio (IV, Random, 95% CI)	1.36 [1.05, 1.76]