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. 2022 Sep 12;3:991725. doi: 10.3389/fpain.2022.991725

Figure 6.

Figure 6

Sex-specific changes in tongue tumor immune microenvironment. Representative histogram and scatter plots showing CD3+CD4+ T cell populations in (A) tongue tissue from sham and MOC1 tumors at post inoculation day (PID) 29 and (B) tongue tissue from sham and MOC2 tumors at PID9. The percentage of CD45+ cells that were (C,D) CD3+CD4+ T cells and (E,F) CD3+CD8+ T cells were quantified in male and female tumor-bearing mice and compared across 3 timepoints (MOC1: PID20, 29 and 40; MOC2: PID6, 9, 12; n = 3/sex/timepoint). Representative histogram and scatter plots showing CD11b+Ly6G+ neutrophil populations in (G) tongue tissue from sham and MOC1 tumors at PID40 and (H) tongue tissue from sham and MOC2 tumors at PID12. The percentage of CD45+ cells that were (I,J) CD11b+Ly6G+ neutrophils and (K,L) CD11b+Ly6G−F4/80+ macrophages were quantified in male and female tumor-bearing mice and compared across 3 timepoints (n = 3/sex/timepoint). Two-way ANOVA (sex by time), *p < 0.05, **p < 0.01.