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. 2022 Sep 12;10:1011435. doi: 10.3389/fcell.2022.1011435

FIGURE 3.

FIGURE 3

A scheme of intracellular signal transduction is presented. The inhibitory effect of epigallocatechin-3-gallate (EGCG) on some protein kinase signaling pathways and transcription factors has been shown, as a complex of p65 and p50 subunits. Note: EGFR, Epidermal growth factor receptor; HER 2/3, Human epidermal growth factor receptor 2/3; PI3K, Phosphoinositide 3-kinases; PKC, Protein kinase C; Ras GTP, RAS guanosine triphosphate; NIK, NF-kappa-B-inducing kinase; MKK4, Mitogen-activated protein kinase kinase 4; MEK 1/2, Mitogen-activated protein kinase kinase 1/2; ERK 1/2, Extracellular signal-regulated kinase-1/2; JNK, c-Jun N-terminal Kinase; BAD, BCL2-associated agonist of cell death; PIP 2/3, Prolactin induced protein 2/3; Bcl-xL, B-cell lymphoma-extra large; IKK α, β, γ, Cytokine-responsive IkappaB kinase α, β, γ; IkBα, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Ub, Ubiquitin B; AP-1, Activator protein 1; MMP-9, Matrix metallopeptidase 9; COX-2, cyclooxygenase 2; Bcl-2, B-cell lymphoma-2; c-FLIP, Cellular FLICE-like inhibitory protein; IAP 1/2, Inhibitor of apoptosis 1/2.