Skip to main content
. 2022 Sep 12;10:1011435. doi: 10.3389/fcell.2022.1011435

TABLE 8.

List of polyphenols with antiviral activity.

Polyphenols Virus type Targets/signaling pathways Mechanism of action References
Resveratrol Human herpesvirus 1 and Human herpesvirus 2 ND Significantly reduced skin lesions, and the effectiveness of the drug depended on its concentration, the time of initiation of treatment and the number of applications per day (Docherty et al., 2004), (Docherty et al., 2005)
Epigallocatechin-3-gallate Hepatitis C Virus E1/E2 Inhibition of virion attachment Ciesek et al. (2011)
Epigallocatechin-3-gallate Hepatitis C Virus GT3a and NS3 helicase Binding interaction of virus NS3 helicase active pocket Fatima et al. (2014)
Epigallocatechin-3-gallate Hepatitis B Virus HBsAg, HBeAg and virus DNA Strong anti-HBV activity through decreasing the secretion of HBsAg, HBeAg and extracellular HBV DNA, although perhaps in such a way that the mechanism may interfere with the replication cycle of HBV DNA Pang et al. (2014)
Resveratrol Human papillomavirus p-pRb1, p53, virus E6 and E7 genes Inhibits cervical cancer development by suppressing the transcription and translation of E6 and E7, and also by promoting the apoptosis and G1/S phase transition arrest. Sun et al. (2021)
6-Gingerol Human papillomavirus p53, p21, caspase-3 and PARP Inhibits the chymotrypsin activity of proteasomes; induce reactivation of p53, and DNA damage and G2/M cell cycle arrest; increases levels of p21; and potentiates the cytotoxicity of cisplatin. Rastogi et al. (2015)
Resveratrol Epstein-Barr virus Rta, Zta, and EA-D Inhibits virus lytic cycle Yiu et al. (2010)

GT3a, genotype 3a; NS3, nonstructural protein 3; HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e-antigen; p-pRb1, phosphorylated retinoblastoma protein; PARP, Poly (ADP-ribose) polymerase; HBV, Hepatitis B Virus; ND, not mentioned.

HHS Vulnerability Disclosure