Table 2.

Canine Brief Pain Inventory (CBPI) assessment comparison of undenatured type II collagen (UC-II) (Lonza Capsules and Health Ingredients, Inc; Morristown, NJ) versus placebo supplemented Labrador Retrievers

Parameter	Timepoint	UC-II	Placebo	SEM	P-value
Pain at worst	Baseline	0.48b	0.58b	0.12	0.681
	Pre 5 km	0.45b	0.63b	0.12	0.467
	Post 5 km	0.60ab	1.43ab	0.18	0.021
	Pre 16 km	0.75ab	1.38ab	0.19	0.105
	Post 16 km	1.25a	2.05a	0.24	0.097
Pain at least	Baseline	0.15	0.35	0.07	0.155
	Pre 5 km	0.15	0.35	0.07	0.155
	Post 5 km	0.15	0.50	0.07	0.015
	Pre 16 km	0.15	0.35	0.06	0.098
	Post 16 km	0.25	0.55	0.08	0.063
Pain at average	Baseline	0.20b	0.45	0.09	0.176
	Pre 5 km	0.15b	0.45	0.09	0.101
	Post 5 km	0.23b	0.70	0.11	0.025
	Pre 16 km	0.33ab	0.58	0.09	0.177
	Post 16 km	0.73a	1.15	0.16	0.187
Pain as it is now	Baseline	0.18b	0.45b	0.09	0.134
	Pre 5 km	0.15b	0.45b	0.09	0.101
	Post 5 km	0.28b	0.60b	0.11	0.144
	Pre 16 km	0.30ab	0.58b	0.10	0.186
	Post 16 km	0.70a	1.45a	0.19	0.046
Pain during general activity	Baseline	0.08b	0.20b	0.06	0.287
	Pre 5 km	0.05b	0.23ab	0.06	0.152
	Post 5 km	0.10b	0.33ab	0.08	0.166
	Pre 16 km	0.25b	0.45ab	0.09	0.283
	Post 16 km	0.65a	0.85a	0.15	0.501
Enjoyment of life	Baseline	0.00b	0.08	0.02	0.079
	Pre 5 km	0.00b	0.13	0.04	0.092
	Post 5 km	0.00b	0.15	0.05	0.156
	Pre 16 km	0.05ab	0.23	0.06	0.152
	Post 16 km	0.20a	0.43	0.11	0.305
Ability to rise	Baseline	0.00b	0.08b	0.02	0.079
	Pre 5 km	0.00b	0.18ab	0.05	0.105
	Post 5 km	0.00b	0.13b	0.04	0.092
	Pre 16 km	0.18a	0.33ab	0.08	0.355
	Post 16 km	0.33a	0.63a	0.12	0.200
Ability to walk	Baseline	0.23	0.30b	0.07	0.573
	Pre 5 km	0.20	0.30b	0.07	0.448
	Post 5 km	0.20	0.43ab	0.08	0.175
	Pre 16 km	0.38	0.48ab	0.10	0.627
	Post 16 km	0.50	0.93a	0.14	0.118
Ability to run	Baseline	0.23b	0.30b	0.07	0.573
	Pre 5 km	0.23b	0.30b	0.07	0.573
	Post 5 km	0.20b	0.45b	0.09	0.159
	Pre 16 km	0.38ab	0.60ab	0.13	0.375
	Post 16 km	0.85a	1.28a	0.20	0.291
Ability to climb up	Baseline	0.03b	0.08	0.02	0.311
	Pre 5 km	0.00b	0.08	0.02	0.079
	Post 5 km	0.00b	0.13	0.04	0.092
	Pre 16 km	0.05ab	0.33	0.09	0.116
	Post 16 km	0.20a	0.53	0.11	0.146
Quality of life	Baseline	1.13	1.13	0.04	0.999
	Pre 5 km	1.15	1.13	0.04	0.749
	Post 5 km	1.15	1.20	0.05	0.638
	Pre 16 km	1.23	1.28	0.07	0.715
	Post 16 km	1.28	1.35	0.08	0.645

Timepoints include prior to starting treatments or exercise (baseline), prior to the first 5 km run (pre 5 km), 24 h after the first 5 km run (post 5 km), prior to the final 16 km run (pre 16 km), and 24 h after the final 16 km run (post 16 km). Dogs were scored on an 11-point scale of 0 to 10, with higher values correlating to increased pain. Values are presented as least squared means with their standard error.