Table 3.
Liverpool Osteoarthritis in Dogs (LOAD) assessment comparison of undenatured type II collagen (UC-II) (Lonza Capsules and Health Ingredients, Inc. Morristown, NJ) versus placebo supplemented Labrador Retrievers
| Parameter | Timepoint | UC-II | Placebo | SEM | P-value |
|---|---|---|---|---|---|
| How mobile is the dog? | Baseline | 1.15 | 1.13 | 0.04 | 0.749 |
| Pre 5 km | 1.13 | 1.18 | 0.04 | 0.537 | |
| Post 5 km | 1.20 | 1.18 | 0.05 | 0.807 | |
| Pre 16 km | 1.28 | 1.35 | 0.07 | 0.597 | |
| Post 16 km | 1.30 | 1.43 | 0.08 | 0.414 | |
| How disabled is the dog by lameness? | Baseline | 1.13 | 1.10 | 0.04 | 0.728 |
| Pre 5 km | 1.10 | 1.10 | 0.03 | 0.999 | |
| Post 5 km | 1.15 | 1.10 | 0.04 | 0.505 | |
| Pre 16 km | 1.25 | 1.23 | 0.06 | 0.842 | |
| Post 16 km | 1.30 | 1.28 | 0.07 | 0.862 | |
| How active is the dog? | Baseline | 1.20 | 1.45 | 0.07 | 0.077 |
| Pre 5 km | 1.18 | 1.50 | 0.08 | 0.030 | |
| Post 5 km | 1.30 | 1.50 | 0.08 | 0.229 | |
| Pre 16 km | 1.40 | 1.58 | 0.09 | 0.328 | |
| Post 16 km | 1.43 | 1.70 | 0.10 | 0.151 | |
| Effect of cold or damp weather | Baseline | 1.05 | 1.18 | 0.04 | 0.153 |
| Pre 5 km | 1.08 | 1.18 | 0.04 | 0.268 | |
| Post 5 km | 1.18 | 1.18 | 0.05 | 0.999 | |
| Pre 16 km | 1.20 | 1.18 | 0.05 | 0.807 | |
| Post 16 km | 1.23 | 1.18 | 0.05 | 0.649 | |
| Stiffness after a lie down | Baseline | 1.03 | 1.10 | 0.03 | 0.170 |
| Pre 5 km | 1.00 | 1.10 | 0.02 | 0.041 | |
| Post 5 km | 1.05 | 1.10 | 0.03 | 0.402 | |
| Pre 16 km | 1.23 | 1.15 | 0.06 | 0.511 | |
| Post 16 km | 1.23 | 1.30 | 0.07 | 0.586 | |
| At exercise, how active is the dog? | Baseline | 1.30 | 1.33 | 0.07 | 0.864 |
| Pre 5 km | 1.30 | 1.40 | 0.07 | 0.500 | |
| Post 5 km | 1.48 | 1.45 | 0.09 | 0.889 | |
| Pre 16 km | 1.60 | 1.53 | 0.10 | 0.715 | |
| Post 16 km | 1.63 | 1.60 | 0.10 | 0.904 | |
| How keen is the dog to exercise? | Baseline | 1.15b | 1.23 | 0.05 | 0.488 |
| Pre 5 km | 1.15b | 1.25 | 0.05 | 0.363 | |
| Post 5 km | 1.35ab | 1.28 | 0.07 | 0.597 | |
| Pre 16 km | 1.55ab | 1.48 | 0.09 | 0.693 | |
| Post 16 km | 1.58a | 1.58 | 0.10 | 0.999 | |
| How is the dog’s ability to exercise? | Baseline | 1.15 | 1.20 | 0.04 | 0.562 |
| Pre 5 km | 1.15 | 1.25 | 0.05 | 0.269 | |
| Post 5 km | 1.25 | 1.25 | 0.05 | 0.999 | |
| Pre 16 km | 1.33 | 1.43 | 0.08 | 0.516 | |
| Post 16 km | 1.38 | 1.48 | 0.08 | 0.550 | |
| What effect does exercise have on the dog’s lameness? | Baseline | 1.18 | 1.15 | 0.05 | 0.799 |
| Pre 5 km | 1.15 | 1.18 | 0.05 | 0.799 | |
| Post 5 km | 1.15 | 1.18 | 0.05 | 0.799 | |
| Pre 16 km | 1.25 | 1.33 | 0.07 | 0.579 | |
| Post 16 km | 1.35 | 1.50 | 0.08 | 0.358 | |
| How often does the dog rest during exercise? | Baseline | 1.15 | 1.15 | 0.07 | 0.999 |
| Pre 5 km | 1.18 | 1.18 | 0.07 | 0.999 | |
| Post 5 km | 1.30 | 1.23 | 0.07 | 0.573 | |
| Pre 16 km | 1.35 | 1.35 | 0.07 | 0.999 | |
| Post 16 km | 1.43 | 1.45 | 0.07 | 0.899 |
Timepoints include prior to starting treatments or exercise (baseline), prior to the first 5 km run (pre 5 km), 24 h after the first 5 km run (post 5 km), prior to the final 16 km run (pre 16 km), and 24 h after the final 16 km run (post 16 km). Scoring was based on a 5-point scale from 1 to 5, with higher values correlating with increased abnormal behavior, mobility, and exercise. Values are presented as least squared means with their standard error.