Table 3. Clinical outcomes in EPIC and control groups.
| Outcomes | EPIC (N = 395) % (n) |
Control (N = 446) % (n) |
Estimator | Crude | IPTWa | Doubly robust adjustmentb |
|---|---|---|---|---|---|---|
| Primary outcome | ||||||
| Overall mortality at day 28 since hospital admission | 15.7 (62) | 21.5 (96) | OR | 0.68 (95% CI 0.48–0.97) p 0.031 |
0.66 (95% CI 0.46–0.96) p 0.030 |
0.65 (95% CI 0.44–0.98) p 0.038 |
| HR | 0.72 (95% CI 0.52–0.99) p 0.041 |
0.70 (95% CI 0.50–0.98) p 0.037 |
0.72 (95% CI 0.50–1.01) p 0.060 |
|||
| Secondary outcomes | ||||||
| Overall mortality at day 21 since hospital admission | 14.9 (59) | 19.3 (86) | OR | 0.73 (95% CI 0.51–1.05) p 0.094 |
0.72 (95% CI 0.49–1.06) p 0.093 |
0.73 (95% CI 0.48–1.10) p 0.127 |
| Overall mortality at day 14 since hospital admission | 11.1 (44) | 13.5 (60) | OR | 0.80 (95% CI 0.53–1.21) p 0.304 |
0.81 (95% CI 0.52–1.26) p 0.346 |
0.86 (95% CI 0.53–1.39) p 0.533 |
| Status in WHO 6-points ordinal scale: | ||||||
|
WHO 6-points ordinal scale at day 28 1 Full restitution 2 Incomplete restitution 3 Hospitalized NO oxygen 4 Hospitalized with oxygen 5 Invasive ventilatory 6 Death |
76.5 (302) 2 (8) 1.3 (5) 0.5 (2) 4.1 (16) 15.7 (62) |
71.2 (31) 4.5 (20) 0.4 (2) 0.4 (2) 1.8 (8) 21.5 (96) |
Proportional OR |
0.75 (95% CI 0.55–1.02) p 0.07 |
0.74 (95% CI 0.54–1.03) p 0.071 |
0.71 (95% CI 0.50–1) p 0.054 |
|
WHO 6-points ordinal scale at day 21 1 Full restitution 2 Incomplete restitution 3 Hospitalized NO oxygen 4 Hospitalized with oxygen 5 Invasive ventilatory 6 Death |
74.2 (293) 2 (8) 1.3 (5) 2.8 (11) 4.8 (19) 14.9 (59) |
69.3 (31) 3.6 (16) 0.2 (1) 4.3 (19) 3.1 (14) 19.3 (86) |
Proportional OR |
0.79 (95% CI 0.58–1.06) p 0.117 |
0.79 (95% CI 0.57–1.08) p 0.133 |
0.75 (95% CI 0.54–1.06) p 0.101 |
|
WHO 6-points ordinal scale at day 14 1 Full restitution 2 Incomplete restitution 3 Hospitalized NO oxygen 4 Hospitalized with oxygen 5 Invasive ventilatory 6 Death |
68.6 (271) 2.3 (9) 2.3 (9) 7.1 (28) 8.6 (34) 11.1 (44) |
60.3 (27) 2.7 (12) 2.5 (11) 12.3 (55) 8.5 (38) 13.5 (60) |
Proportional OR |
0.73 (95% CI 0.55–0.96) p 0.026 |
0.71 (95% CI 0.53–0.95) p 0.021 |
0.68 (95% CI 0.50–0.94) p 0.019 |
| Proportion of adverse events | 24.8 (98) | 27.1 (121) | OR | 0.86 (95% CI 0.63–1.18) p 0.349 |
0.82 (95% CI 0.59–1.13) p 0.227 |
0.81 (95% CI 0.57–1.16) p 0.257 |
OR: odds ratio, HR: hazard ratio, sHR:sub-hazard ratio
a IPTW
b Doubly robust adjustment