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Evaluation of histological scores.
| Epithelium (E) | Score | Infiltration (I) | Score |
| Normal morphology | 0 | No infiltration | 0 |
| Loss of goblet cells | 1 | Infiltration around crypt bases | 1 |
| Loss of goblet cells in large areas | 2 | Infiltration reaching the muscularis mucosa | 2 |
| Loss of crypt | 3 | Extensive infiltration reaching the muscularis mucosa and thickening of the mucosa with abundant edema | 3 |
| Loss of crypts in large areas | 4 | Infiltration of the submucosa | 4 |
