Table 1.
Comparison of Baseline Patient Data Between the Non-Sepsis Group and Sepsis Group
| Demographic Characteristics | Non-Septic (n=65) | Sepsis (n=63) | Total (n=128) | P value |
|---|---|---|---|---|
| Age, median (range) | 70(30–90) | 79(34–95) | 72(30–95) | 0.004** |
| Sex, Male, n (%) | 44(67.7) | 40(63.5) | 84(65.6) | 0.511 |
| MAP (mmHg) | 106.47(21.06) | 92.14(23.07) | 97.5(84.75–114) | 0.000*** |
| Comorbidities | ||||
| Acute cerebrovascular disease, n (%) | 19(29.2) | 23(36.5) | 42 (32.8) | 0.686 |
| Diabetes mellitus, n (%) | 22(33.8) | 20(31.7) | 42 (32.8) | 0.220 |
| Cardiovascular disease, n (%) | 28(43.1) | 6(9.5) | 34 (26.6) | 0.001** |
| Chronic lung disease, n (%) | 7(10.8) | 14(22.2) | 21 (16.4) | 0.246 |
| Use of vasopressors, n (%) | 3(4.6) | 19(30.2) | 22 (17.7) | 0.008** |
| Use of mechanical ventilation, n (%) | 8(12.3) | 24(38.1) | 32 (25) | 0.142 |
| APHACHE II | 29(16–39) | 33.56(11.91) | 33(20–41) | 0.054 |
| qSOFA | 0(0–1) | 1(0–1) | 1(0–1) | 0.006** |
| SOFA | 1.75(1.5) | 5(3–6) | 3.3(2.36) | 0.000*** |
| GCS | 15(15–15) | 14(12–15) | 15(13–15) | 0.002** |
| Laboratory value | ||||
| PCT (ng/mL) | 0.03(0.01–0.1) | 0.49(0.08–3.1) | 0.09(0.02–0.57) | 0.000*** |
| CRP (mg/dl) | 8.3(0.5–31.8) | 39.8(10.3–98.6) | 23.1(2.08–69.53) | 0.000*** |
| Lac (mmol/L) | 1.25(0.83–1.88) | 1.5(1–2.8) | 1.4(0.9–2.2) | 0.256 |
| Creatinine (umol/L) | 75.3(63–88.85) | 88.8(55.5–124.7) | 78.7(60.05–101.18) | 0.170 |
| Bilirubin (umol/L) | 16.38 (14.63) | 15.9(9.5–23) | 14.95(9.7–21.73) | 0.147 |
| Platelets (× 1000/μL) | 208.85 (60.59) | 189(124–263) | 206.5(150–255.75) | 0.571 |
| IL-6 (pg/mL) | 10.84(4.41–27.01) | 92.22(21.53–201.12) | 23.09(8.32–115.41) | 0.000*** |
| WBC (×109个/L) | 10.2 (4.25) | 11.1(7–15.75) | 10(6.85) | 0.125 |
| BUN (mmol/L) | 7.01(4.90–11.74) | 13.03(6.93–25.99) | 9.71(5.45–19.19) | 0.001** |
Notes: **Means p < 0.01, ***Means p < 0.001. Normally distributed data are expressed as mean ± standard deviation; skewed distributed data are expressed as median and quartile.
Abbreviations: SD, Standard Deviation; MAP, Mean Arterial Pressure; qSOFA, Rapid Sequential Organ Failure Score; SOFA, Sequential Organ Failure Score; APHCHE II, Acute Physiology and Chronic Health Assessment II; GCS, Glasgow Coma Scale; PCT, procalcitonin; CRP, C-reactive protein; IL-6, interleukin-6; WBC, white blood cell count.