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. 2022 Sep 22;15:2967–2988. doi: 10.2147/JPR.S382692

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© 2022 Fang et al.

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The regulatory network of DE miRNAs negatively targeting DE mRNAs. Totally, 30 DE miRNAs were predicted to target 80 DE mRNAs negatively. In the network, 7 DE miRNAs (circles with black border) have been associated with pain, and 4 DE mRNAs (triangles with black border) were related to the known pain genes. The node size is directly proportional to the number of their corresponding partners.