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. 2022 Sep 22;15:2967–2988. doi: 10.2147/JPR.S382692

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© 2022 Fang et al.

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The pain-related protein–protein intersection (PPI) network of the DEGs encoding proteins in the TG of CCI-ION mice. The network was built based on the pain-specific PPI network. Using DEGs in the TG of CCI-ION mice and partner genes from the pain-specific PPI network (DEGs and non-DEGs). The colored arrows represent the type and direction of interactions; The colored nodes mark the expression changes. Totally, 30 up-regulated genes were involved in the pain-specific PPI network, and no down-regulated DEGs were involved in the pain-specific PPI network. DEG, differentially expressed gene; PPI, protein–protein interaction. The size of the node is in direct proportion to the degree.