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. 2022 Sep 22;15:2967–2988. doi: 10.2147/JPR.S382692

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© 2022 Fang et al.

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Regulatory network analysis of DE lncRNA-DE miRNA-DE mRNA in the TG of CCI-ION mice based on the ceRNA regulation theory. (A) The down-regulated DE lncRNAs were predicted to regulate the expression of the down-regulated DE mRNAs by sponging the up-regulated DE miRNAs in the TG of CCI-ION mice. The triangle with a red border (Ctsd) represents the DE mRNA related to pain. (B) The up-regulated lncRNAs were predicted to regulate the expression of the up-regulated mRNAs by sponging the down-regulated miRNAs in the TG of CCI-ION mice, the triangle with a green border (Cacna1a, Il1rl1, and Lmx1b) represents the DE mRNA related to pain. The size of the node is in direct proportion to the degree.