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. 2022 Sep 22;15:2967–2988. doi: 10.2147/JPR.S382692

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© 2022 Fang et al.

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Regulatory network analysis of circRNA-miRNA-mRNA in the TG of CCI-ION mice according to the ceRNA mechanism. The up-regulated circRNAs and down-regulated circRNAs were predicted to regulate the expression of DE mRNAs by sponging DE miRNAs in the TG of CCI-ION mice. The triangles with a black border represent the DE mRNAs related to the known pain genes. The size of the node is in direct proportion to the degree.