Table 3.

In vivo evidence that Inhibiting Uricase is Involved in the Biological Survival Response

Survival Response	Mechanism
Foraging	Increases locomotor activity and hyperactivity (59)
	Increased endurance (60)
	Increases Impulsivity (61)
	Decrease anxiety in stressful situations (62)
	Decrease Recent Memory (hippocampal)(63)
Fat Accumulation	Increases Fat in the Liver (57, 64)
	Hypertriglyceridemia (65)
Impaired Glucose Tolerance	Stimulates Insulin Resistance (66)
	Stimulates Gluconeogenesis (48)
	Reduces Insulin Secretion (67)
Raises Blood Pressure	Reduces nitric oxide (21)
	Stimulates renal and local RAS
	Stimulates aldosterone (68)
	Stimulates endothelin (69)
	Stimulates oxidative stress (17)
	Stimulates COX-2 associated thromboxane (70)
	Increases Renal Sodium Reabsorption (71)
Inflammation	Systemic Inflammatory Markers (72)
	Inflammasome activation (73)
	Alterations in Microbiome/Leaky Gut (74)